We welcomed nearly 100 attendees — 45 in person and 51 online — to the International Guest Lectures in Neurodegenerative Diseases, a joint event with the Brain and Mind Centre’s Alzheimer’s team. The lineup featured Professor Stephen Salloway from Brown University, who shared insights into the development and clinical application of amyloid-lowering therapies for Alzheimer’s disease. There was much interest in hearing also from Associate Professor Heidi Jacobs from Massachusetts General Hospital and Harvard Medical School who, discussed the locus coeruleus as a promising early biomarker for Alzheimer’s risk, as well as the key role of the LC in sleep-wake functions. Building on this, we hosted a dedicated workshop on the locus coeruleus, featuring presentations from Yuhong Fu, Gabriel Wainstein, Claire O’Callaghan, Shawn Kong, and Brandon Munn.